Based in Portland, Oregon, Craft Brew Alliance, Inc. (NASDAQ: BREW), formerly Redhook Ale Brewery, Inc., is an independent craft brewing enterprise. The company established in 2008 through the merger of Widmer Brothers Brewing and Redhook Ale Brewery. In 2010, Craft Brew Alliance acquired Kona Brewing Co.
Craft Brew Alliance could be a long play for small-cap niche investors interested in the company's new focus from solidifying its foundation to its current appetite for growth. However, the fickle nature of consumers' tastes as applies to the beer, wine, and spirits industry, in tandem with the inherent tough competition in the Beverages (Brewers) industry may prevent some investors from investing in the company.
Nevertheless, here's a rundown on the strengths of the company as well as some challenges it faces as a brewer.
Strengths
High-Growth Unique Brands
Craft Brew Alliance has a selection of diverse, original craft beer brands. The company's Kona, Redhook, and Omission brands are driving growth. Kona is its largest brand family, offering Big Wave Golden Ale; Fire Rock Pale Ale; Koko Brown Nut Brown Ale; Wailua Ale, and Pipeline Porter.
Hot Heal Care Companies To Watch In Right Now: Sara Lee Corporation(SLE)
Sara Lee Corporation engages in the manufacture and marketing of a range of branded packaged meat, bakery, and beverage products worldwide. Its packaged meat products include hot dogs and corn dogs, breakfast sausages, sandwiches and bowls, smoked and dinner sausages, premium deli and luncheon meats, bacon, beef, turkey, and cooked ham. It also offers frozen baked products, which comprise frozen pies, cakes, cheesecakes, pastries, and other desserts. In addition, Sara Lee provides roast, ground, and liquid coffee; cappuccinos; lattes; and hot and iced teas, as well as refrigerated dough products. The company sells its products under Hillshire Farm, Ball Park, Jimmy Dean, Sara Lee, State Fair, Douwe Egberts, Senseo, Maison du Caf
Hot Heal Care Companies To Watch In Right Now: Knick Explor (KNX.V)
Knick Exploration Inc. engages in the identification and exploration of mineral properties in Canada. The company explores for gold deposits on its properties located in the Val-d�Or, Quebec and West Timmins, Ontario. Its principal project is the East-West property covering 184 hectares in Dubuisson Township, Quebec. The Company is headquartered in Val-d�Or, Canada.
QLT Inc., a biotechnology company, engages in the development and commercialization of ocular products that address the unmet medical needs of patients and clinicians. It offers Visudyne that utilizes light-activated photodynamic therapy to treat the eye disease known as wet age related macular degeneration. Visudyne is also used for the treatment of subfoveal choroidal neovascularization secondary to pathologic myopia, severe near-sightedness, and presumed ocular histoplasmosis. The company?s developmental stage products include Latanoprost Punctal Plug Drug Delivery System, which is in Phase II clinical trial for the treatment of glaucoma and allergic conjunctivitis; and QLT091001, which is in Phase Ib clinical trial for the treatment of leber congenital amaurosis and retinitis pigmentosa. QLT Inc. markets its products in approximately 80 countries worldwide. The company was founded in 1981 and is headquartered in Vancouver, Canada.
Hot Heal Care Companies To Watch In Right Now: Cell Therapeutics Inc (CTIC)
Cell Therapeutics, Inc. (CTI), incorporated in 1991, develops, acquires and commercializes treatments for cancer. The Company�� research, development, acquisition and in-licensing activities concentrate on identifying and developing new ways to treat cancer. As of December 31, 2011, CTI focused its efforts on Pixuvri (pixantrone dimaleate) (Pixuvri), OPAXIO (paclitaxel poliglumex) (OPAXIO), tosedostat, brostallicin and bisplatinates. As of December 31, 2011, it developed Pixuvri, an anthracycline derivative for the treatment of hematologic malignancies and solid tumors. Another late-stage drug candidate of the Company, OPAXIO, is being studied as a potential maintenance therapy for women with advanced stage ovarian cancer, who achieve a complete remission following first-line therapy with paclitaxel and carboplatin. As of December 31, 2011, it also developed tosedostat in collaboration with Chroma Therapeutics, Ltd. (Chroma). On May 31, 2012, CTI completed its acquisition gaining worldwide rights to S*BIO Pte Ltd.'s (S*BIO) pacritinib.
Pixuvri
As of December 31, 2011, the Company developed Pixuvri, an aza-anthracenedione derivative, for the treatment of non-Hodgkin�� lymphoma (NHL), and various other hematologic malignancies, and solid tumors. Pixuvri was studied in the Company�� EXTEND, or PIX301, clinical trial, which was a phase III single-agent trial of Pixuvri for patients with relapsed, refractory aggressive NHL who received two or more prior therapies and who were sensitive to treatment with anthracyclines. On September 28, 2011, CTI announced that a second independent radiology assessment of response and progression endpoint data from its PIX301 clinical trial of Pixuvri was achieved with statistical significance. The results of the EXTEND trial met its primary endpoint and showed that patients randomized to treatment with Pixuvri achieved a significantly higher rate of confirmed and unconfirmed complete response compared to patients treated with standard chem! otherapy had a significantly increased overall response rate and experienced a statistically significant improvement in median progression free survival. Pixuvri had predictable and manageable toxicities when administered at the proposed dose and schedule in the EXTEND clinical trial in heavily pre-treated patients. In March 2011, the Company initiated the PIX-R trial to study Pixuvri in combination with rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Pixuvri has also been studied in patients with HER2-negative metastatic breast cancer who have tumor progression after at least two, but not more than three, prior chemotherapy regimens. In the second quarter of 2010, the NCCTG opened this phase II study for enrollment. The study is closed to accrual and results are expected to be reported by the NCCTG later in 2012.
OPAXIO
OPAXIO is the Company�� biologically-enhanced chemotherapeutic agent that links paclitaxel to a biodegradable polyglutamate polymer, resulting in a new chemical entity. As of December 31, 2011, the Company focused its development of OPAXIO on ovarian, brain, esophageal, head and neck cancer. OPAXIO was designed to improve the delivery of paclitaxel to tumor tissue while protecting normal tissue from toxic side effects. In November 2010, results were presented by the Brown University Oncology Group from a phase II trial of OPAXIO combined with temozolomide (TMZ), and radiotherapy in patients with newly-diagnosed, high-grade gliomas, a type of brain cancer. The trial demonstrated a high rate of complete and partial responses and a high rate of six month progression free survival (PFS). Based on these results, the Brown University Oncology Group has initiated a randomized, multicenter, phase II study of OPAXIO and standard radiotherapy versus TMZ and radiotherapy for newly diagnosed patients with glioblastoma with an active gene termed MGMT that reduces responsiveness to TMZ. A phase I/II study of OPAXIO combined with radi! otherapy ! and cisplatin was initiated by SUNY Upstate Medical University, in patients with locally advanced head and neck cancer.
Tosedostat
In March 2011, the Company entered into a co-development and license agreement with Chroma Therapeutics, Ltd. (Chroma), providing the Company with marketing and co-development rights to Chroma�� drug candidate, tosedostat, in North, Central and South America. Tosedostat is an oral, aminopeptidase inhibitor that has demonstrated anti-tumor responses in blood related cancers and solid tumors in phase I-II clinical trials. Interim results from the phase II OPAL study of tosedostat in elderly patients with relapsed or refractory acute myeloid leukemia (AML) showed that once-daily, oral doses of tosedostat had predictable and manageable toxicities and results demonstrated response rates, including a high-response rate among patients who received prior hypomethylating agents, which are used to treat myelodysplastic syndrome (MDS), a precursor of AML.
Brostallicin
As of December 31, 2011, the Company developed brostallicin through its wholly owned subsidiary, Systems Medicine LLC, which holds rights to use, develop, import and export brostallicin. Brostallicin is a synthetic deoxyribonucleic acid (DNA) minor groove binding agent that has demonstrated anti-tumor activity and a favorable safety profile in clinical trials, in which more than 230 patients have been treated as of December 31, 2011. The Company uses a genomic-based platform to guide the development of brostallicin. A phase II study of brostallicin in relapsed, refractory soft tissue sarcoma met its predefined activity and safety hurdles and resulted in a first-line phase II clinical trial study that was conducted by the European Organization for Research and Treatment of Cancer (EORTC).
The Company competes with Bristol-Myers Squibb Company, Sanofi-Aventis, Pfizer, Roche Group, Genentech, Inc., Astellas Pharma, Eli Lilly and Company, Celgene, Telik, I! nc., TEVA! Pharmaceuticals Industries Ltd. and PharmaMar.
Advisors' Opinion: - [By John Udovich]
If you have not been watching the biotech sector lately, you should start paying attention as the sector along with small cap biotech stocks like Cell Therapeutics Inc (NASDAQ: CTIC), BIND Therapeutics Inc (NASDAQ: BIND) and TNI BioTech (OTCMKTS: TNIB) continue to produce a steady stream of good news for investors thanks to positive industry trends. Moreover, Ophthotech Corp (NASDAQ: OPHT), Foundation Medicine Inc (NASDAQ: FMI), Evoke Pharma and Fate Therapeutics Inc (NASDAQ: FATE) are this week's biotech IPOs that will no doubt be watched closely by Wall Street and industry observers in general. With that in mind, consider the following biotech news or recent articles about the industry and the small cap players in it:
Hot Heal Care Companies To Watch In Right Now: ENTERTAINMENT ONE LTD ORD CAD0.01(ETO.L)
Entertainment One Ltd. engages in the acquisition, production, and distribution of film and television content primarily in Canada, the United States, the United Kingdom, and other countries in Europe. The company operates as an integrated producer, distributor, and international sales agent of feature films and television programming. It offers a range of product genres, including independent films, TV on DVD, children?s programs, special interest, and music, as well as owns long term rights to theatrical, home entertainment, and TV titles. The company also engages in producing series, mini-series, television movies, and documentaries; international film and TV licensing, such as eclectic mix of programming from scripted series to kids? programming, animation, reality, factual, and movies; and TV broadcast sales, home video, and merchandising licenses, as well as provides digital music and video content for digital service providers. It has a rights library of approxima tely 20,000 film and television titles; and 2,500 hours of television programming. In addition, the company is involved in the wholesale of DVDs, CDs, and video games, as well as music and video through physical and digital channels to retail partners. Entertainment One Ltd. was founded in 1973 and is based in Toronto, Canada.
Hot Heal Care Companies To Watch In Right Now: Celeste Mining Corp.(C.V)
Celeste Mining Corp., a junior natural resource company, engages in the acquisition, exploration, and development of mineral properties in Chile. It primarily explores for tin, copper, gold, and silver ores. The company holds an option agreement to acquire a 100% interest in seven exploration concessions, Celeste IV�X, covering approximately 2,765 hectares located in the Cabeza de Vaca mineral district, Chile. It also holds three exploration concessions in the Manto Medio district of Chile. The company was formerly known as Celeste Copper Corporation and changed its name to Celeste Mining Corp. in November 2012. Celeste Mining Corp. was incorporated in 2007 and is based in Calgary, Canada.
Hot Heal Care Companies To Watch In Right Now: New Hampshire Thrift Bancshares Inc.(NHTB)
New Hampshire Thrift Bancshares, Inc. operates as the holding company for Lake Sunapee Bank, fsb that provides banking and other financial services in New Hampshire and Vermont. The company accepts various deposit products, including business checking, money market accounts, savings, negotiable order of withdrawal, and certificate accounts. Its loan portfolio comprises real estate loans, real estate construction loans, consumer loans, commercial loans, and municipal loans. The company also sells brokerage, securities, and insurance products. It operates 28 branches in Grafton, Hillsborough, Sullivan, Chester, and Merrimack counties in west central New Hampshire; and in Rutland and Windsor counties in Vermont. The company was founded in 1868 and is headquartered in Newport, New Hampshire.
Hot Heal Care Companies To Watch In Right Now: TeleTech Holdings Inc.(TTEC)
TeleTech Holdings, Inc., together with its subsidiaries, provides customer experience strategy, technology, and business process outsourcing solutions worldwide. The company offers revenue generation solutions, including designing and managing approximately 8,000 client-branded e-commerce Websites, and processing 3 terabytes of customer data daily to create and implement customer targeting and segmentation strategies to enhance customer acquisition, retention, and growth. It also offers customer innovation solutions that integrate voice, chat, e-mail, ecommerce, and social media to enhance the customer experience for its clients; and enterprise innovation solutions that comprise redesigning and managing clients? back-office processes to enhance clients? abilities to obtain a customer-centric view of their relationships. In addition, the company provides managed technology solutions consisting of software and infrastructure as a service; and designing, implementing, and m anaging clients? premise-based delivery center environments to enable companies to deliver a customer experience across various touch points. Further, it offers learning innovation training solutions that utilizes a methodology, which includes virtual job-simulation environments, eLearning courses, interactive social media networking, and collaboration, as well as intuitive 3D and game-based learning courses; data analytics to provide real time and actionable customer insight regarding how to grow revenue, reduce customer churn, and enhance operating efficiencies; and professional services to deliver customer-centric solutions. The company serves automotive, broadband, cable, financial services, healthcare, logistics, media and entertainment, retail, technology, travel, and wireline and wireless communication industries. TeleTech Holdings, Inc. was founded in 1982 and is headquartered in Englewood, Colorado.